iloperidone increases amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone is usually a time-dependent CYP3A inhibitor and could cause enhanced plasma amounts of medicines predominantly removed by CYP3A4.Ferraro et al (1997b) examined the in vivo dopamine and GABA levels of the nucleus accumb